It's All In The Genes

Question:  A 53 year old male undergoes transoral laser microsurgery for a T2N2bM0 squamous cell carcinoma of the left palatine tonsil.  Pathology reveals a moderately to poorly differentiated SCC that is P16 positive.  Which gene(s) is/are responsible for tumorigenesis in this patient?  [Answer will be posted with next week's new question]

Answer to last week's question, "The Telescoping Nose" (April 25, 2016): 

Markowitz class 1.